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Early career researchers Drs. Shihab Shah and Varinder Lall have successfully secured funding for their pioneering research on pain mechanisms. Dr Varinder Lall has been awarded funding from the Medical Research Council for a £749,000 project titled “Investigating peripheral gating of pain using novel preclinical model”. Dr Lall is a Researcher Co-Lead on this new...
Perceptual constancy allows us to recognize objects consistently, regardless of changes in distance or sensory input. This ability develops in infancy and is essential for understanding our environment. However, until recently, little was known about how the brain acquires this skill. A new study published in Science Advances sheds light on this process. The Johnston...
Three research groups in the School of Biomedical Sciences recently secured new funding: Professor Nikita Gamper leading a MRC Program grant (industrial collaboration Framework) in collaboration with Marzia Malcangio of Kings College London, Mauro Perretti of Queen Mary's University London and Eli Lilly & Co has acquired funding for a £3.5 million project to explore...
A new study by Dr Marine Krzisch has identified the role of the brain's immune system in Parkinson's disease. Microglia are brain cells that defend the brain against pathogens. In Parkinson’s disease, microglia get activated: they become hyper-alert, and it is thought they damage neurons. However, their exact role had remained unclear. In this study,...
The Frank group investigating Alzheimer’s disease has determined the structure of molecules within a human brain for the very first time. Published in Nature, the study describes using cryo-electron tomography, guided by fluorescence microscopy, to explore deep inside an Alzheimer’s disease donor brain. This gave 3-dimensional maps in which they could observe proteins, the molecular building blocks of...
A new collaborative study from the laboratories of Nikita Gamper (University of Leeds), Xiaona Du (Hebei Medical University) and Temugin Berta (University of Cincinnati) has uncovered a novel peripheral mechanism of pain processing. The team discovered that our body uses its own version of benzodiazepine-like drugs to control some types of pain. Benzodiazepines are a...
Programme: 09:15-09:50: Coffee and Registration 09:50-10:00: Introduction/Welcome Session 1 10:00-10:20: Ronaldo Ichiyama - Spinal Cord Injuries: Neural Plasticity and Functional Repair 10:20-10:40: Emmanuele Tidoni - Exploring Human-Robot Interactions through the Lens of Social Neuroscience 10:40-11:00: Samit Chakrabarty - TBC 11:00-11:20: Faisal Mustaq - City-Scale Neuroscience: Tracking Adolescent Brain Development in the Born in Bradford Longitudinal Study 11:20-11:40: James Poulter – Neur@L and the British Neuroscience Association 11:40-12:00: Ali...
Programme: Coffee/Tea from 9:15-9:45. 09:45-09:50: Introduction and welcome by Dr René Frank Session chaired by Prof Susan Deuchars 09:50-10:10: Prof Nikita Gamper (School Biomedical Sciences). 'Modulation of somatosensory information flow at the dorsal root ganglion'. 10:10-10:30: Dr Lucy Stead (School of Medicine). 'Glioblastoma: patient stratification and a role for neurotransmitter signaling'. 10:30-10:50: Dr Matthew Mulvey...
REST silencing results in hearing loss due to up regulation of Kv7 in the cochlea published in eLife Repressor element 1-silencing transcription factor (REST) is a transcriptional repressor that orchestrates large-scale changes in gene expression patterns. Although originally recognised as a suppressor of neuronal genes in non-neuronal cells, REST is now increasingly recognised for its...
We congratulate Dr René Frank for the award of a UKRI Future Leaders Fellowship entitled ‘The architecture of Alzheimer’s disease-associated pathology by cryo-electron tomography’, which provides £1.74million over 4 years to support René and his team. The fellowship will bridge length-scales from molecules to the whole brain to identify the in situ structural basis of...